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The Gerontologist, Vol 33, Issue 5 637-643, Copyright © 1993 by The Gerontological Society of America

ARTICLES

Changes in semantic memory in early stage Alzheimer's disease patients

HJ Weingartner, C Kawas, R Rawlings and M Shapiro
Cognitive Neurosciences Section, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.

The types and number of exemplars of categories that are retrieved from semantic memory differentiate elderly normal controls and early stage Alzheimer's disease (AD) patients. Elderly normal controls generated more uncommon exemplars from closed semantic categories (fruits and vegetables) than did AD patients 2 1/2 years prior to the presumed onset of AD. AD patients, however, were just as productive as elderly normal controls in generating associations to open categories (letters). The findings suggest that one of the early cognitive symptoms of AD is changes in availability of uncommon exemplars of semantic networks.


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C. L. Grady, A. R. McIntosh, S. Beig, M. L. Keightley, H. Burian, and S. E. Black
Evidence from Functional Neuroimaging of a Compensatory Prefrontal Network in Alzheimer's Disease
J. Neurosci., February 1, 2003; 23(3): 986 - 993.
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